| Sarah Michelle Gellar as Kathryn Merteuil |
| Ryan Phillippe as Sebastian Valmont |
| Reese Witherspoon as Annette Hargrove |
| Selma Blair as Cecile Caldwell |
| Joshua Jackson as Blaine Tuttle |
| Eric Mabius as Greg McConnell |
| Sean Patrick Thomas as Ronald Clifford |
| Swoozie Kurtz as Dr. Greenbaum |
| Christine Baranski as Bunny Caldwell |
| Louise Fletcher as Helen Rosemond |
| Alaina Reed Hall as Nurse |
| Deborah Offner as Mrs.Michalak |
| Tara Reid as Marci Greenbaum |
| Herta Ware as Mrs.Sugarman |
| Hiep Thi Lee as Mai-Lee |
| Charlie O'Connell as Court Reynolds |
| Fred Norris as Meter Maid |
| Ginger Williams as Clorissa |
| Drew Snyder as Headmaster Hargrove |